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cAMP (C. S. Nunemaker and L. S. Satin, unpublished). This is consistent with the report of Beauvois et al. ((62), Fig. 5) that forskolin could not elicit Ca21 release in islets from. NMRI mice but could do so in the ob/ob islets used by Liu et al. (43). Our results, especially the finding of conversion from fast to slow oscillations by.

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glucose can control insulin release independently from changes in K+-ATP channel activity and in membrane potential (Gem- bal et al. 1992. J. Clin. Invest. 89:1288-1295). phosphates by vasopressin or cAMP by forskolin, and activat- ing protein. Cook, D. L., L. S. Satin, M. L. J. Ashford, and C. N. Hales. 1988. ATP-.

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1 Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,

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